Perinatal Nursing & Adolescent Psychiatry

Biography

Biography: Yu-Kai Du

Abstract

Objective: Many epidemiologic studies have consistently shown that cigarette smoking during pregnancy could increase the risk for children neurodevelopmental disorders and behavioral problems, but the gene-environment interaction of smoke exposure and gene influence is numbered. The purpose of our study was to test the hypothesis that prenatal tobacco smoke exposure(including maternal smoking and secondhand smoke exposure during pregnancy) could modify the association of genetic variants with diagnosed ADHD and ADHD co-occurring ODD (ADHD-ODD).Methodology: The simple effects of certain single nucleotide polymorphisms (SNPs) in the dopaminergic, serotonergic, and noradrenergic pathway and of prenatal tobacco smoke exposure in association with ADHD and ADHD-ODD were estimated, the joint effects, in addition, of SNPs and prenatal tobacco smoke exposure were measured using unconditional univariate logistic regression analysis adjusting by potential influences, such as preterm birth, low birth weight, lead. Findings: Prenatal tobacco smoke exposure was an important risk factor of children diagnosed ADHD even by adjusted other potential confounders. We found three SNPs in the ADRA2A, DRD2 and SLC6A4 genes were statistical associated with diagnosed ADHD, but the relationships were disappeared in some symptom domain. The risk of the genetic variants in the children ADHD symptom domains and ADHD-ODD were increased sharply when combined prenatal tobacco smoke exposure. Conclusion: The genetic variants and prenatal tobacco smoke exposure were in associated with astrong increased risk of ADHD and ADHD-ODD. These findings suggested that the genetic risk factors for ADHD could